Erythema induratum of Bazin is a chronic, nodular eruption that usually occurs on the lower legs of young women. It has been regarded as a manifestation of tuberculin hypersensitivity, a type of tuberculid occurring on the legs, whereas nodular vasculitis represents the nontuberculous counterpart. The number of reports of erythema induratum of Bazin is decreasing in most developed countries in accordance with the decreased incidence of tuberculosis. The etiopathogenesis of erythema induratum of Bazin and its relation to tuberculosis are still controversial, because mycobacteria cannot be cultured from the skin lesions.
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Professional Reference articles are designed for health professionals to use. You may find one of our health articles more useful. Synonyms: Bazin's disease, nodular vasculitis, tuberculous erythema induratum, tuberculosum, tuberculosis cutis indurativa and nodose tuberculid. Erythema induratum is a rare condition that classically produces painful, firm and sometimes ulcerated nodules on the lower legs in association with tuberculosis TB.
In the term nodular vasculitis was coined to describe chronic inflammatory nodules of the legs that showed histopathological changes similar to those of erythema induratum, but without an association with TB. The vasculitis is of the larger vessels with panniculitis - an inflammation involving subcutaneous fat and occasionally muscle, with or without vasculitis. Erythema induratum and nodular vasculitis had been seen as the same disease for many years but nodular vasculitis is now considered to be a multifactorial syndrome of lobular panniculitis in which tuberculosis may or may not be one of the various aetiologies.
The disease or diseases represent an inflammatory reaction. One antigen is Mycobacterium tuberculosis. Patients with erythema induratum have a strongly positive tuberculin skin test and a marked increase in their peripheral T-lymphocyte response to purified protein derivative PPD of tuberculin, which is a delayed type IV hypersensitivity reaction. In cases of erythema induratum with a negative tuberculin test, the cause is often unknown but there have been case reports of an association of erythema induratum with infectious disorders caused by nocardia, Pseudomonas spp.
Gilchrist H, Patterson JW ; Erythema nodosum and erythema induratum nodular vasculitis : diagnosis and management. Dermatol Ther. J Clin Aesthet Dermatol. Arch Dermatol. Prajapati V, Steed M, Grewal P, et al ; Erythema induratum: case series illustrating the utility of the interferon-gamma release assay in determining the association with tuberculosis.
J Cutan Med Surg. Dermatol Online J. Hello everyone,I need help. This is been going for over 1 year now. Have seen many doctors and lab work always comes good. They don't know what it could be and in the end they say it is Alopecia Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions.
This article is for Medical Professionals. Synonyms: Bazin's disease, nodular vasculitis, tuberculous erythema induratum, tuberculosum, tuberculosis cutis indurativa and nodose tuberculid Trending Articles.
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Erythema induratum also referred to as erythema induratum of Bazin EIB or nodular vasculitis is a chronic nodular skin disease that is thought to represent a hypersensitivity response to Mycobacterium tuberculosis or its antigens. Erythema induratum classically presents during early adolescence and peri-menopause as subcutaneous poorly defined erythematous plaques and tender violaceous nodules. The disease preferentially affects the posterior and anterolateral aspects of the lower legs of women; however it can occur in other locations as well as in men and children. Continue Reading. Patients may describe a prolonged history of recurrent episodes over years or decades with new crops of lesions appearing often unpredictably.
Erythema Induratum of Bazin
Erythema induratum is a panniculitis on the calves. It occurs mainly in women, but it is very rare now. Historically, when it has occurred, it has often been concomitant with cutaneous tuberculosis , and it was formerly thought to be always a reaction to the TB bacteria. It is now considered a panniculitis that is not associated with just a single defined pathogen. Predisposing factors include abnormal amount of subcutaneous fat, thick ankles and abnormally poor arterial supply. Abnormal arterial supply causes low-grade ischemia of ankle region. The ankle skin becomes sensitive to temperature changes.